Karen B Whittington Selected Research

HLA-DR1 Antigen (HLA DR1 Antigen)

1/2022	CD8+ T Cells Expressing an HLA-DR1 Chimeric Antigen Receptor Target Autoimmune CD4+ T Cells in an Antigen-Specific Manner and Inhibit the Development of Autoimmune Arthritis.
1/2021	The role of posttranslational modifications in generating neo-epitopes that bind to rheumatoid arthritis-associated HLA-DR alleles and promote autoimmune T cell responses.
7/2010	An autoantigen-specific, highly restricted T cell repertoire infiltrates the arthritic joints of mice in an HLA-DR1 humanized mouse model of autoimmune arthritis.
9/2006	Crystallographic structure of a rheumatoid arthritis MHC susceptibility allele, HLA-DR1 (DRB1*0101), complexed with the immunodominant determinant of human type II collagen.
4/2005	Ex vivo characterization of the autoimmune T cell response in the HLA-DR1 mouse model of collagen-induced arthritis reveals long-term activation of type II collagen-specific cells and their presence in arthritic joints.
4/2004	Collagen-induced arthritis mediated by HLA-DR1 (0101) and HLA-DR4 (0401).

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Karen B Whittington Research Topics

Disease

8	Arthritis (Polyarthritis) 01/2022 - 01/2002
6	Rheumatoid Arthritis 01/2021 - 01/2002
3	Experimental Arthritis 04/2005 - 01/2002
2	Autoimmune Diseases (Autoimmune Disease) 01/2022 - 01/2002
1	Periodontal Diseases (Periodontal Disease) 10/2016
1	Inflammation (Inflammations) 07/2010

Drug/Important Bio-Agent (IBA)

6	HLA-DR1 Antigen (HLA DR1 Antigen)IBA 01/2022 - 04/2004
6	Collagen Type II (Type II Collagen)IBA 01/2021 - 01/2002
5	HLA-DR Antigens (HLA-DR)IBA 01/2022 - 01/2002
2	AntigensIBA 01/2022 - 04/2004
2	EpitopesIBA 01/2021 - 10/2016
2	AutoantigensIBA 01/2021 - 07/2010
2	EnzymesIBA 10/2016 - 01/2016
2	ImmunosorbentsIBA 10/2016 - 01/2016
2	CytokinesIBA 10/2016 - 01/2002
2	Peptides (Polypeptides)IBA 06/2013 - 04/2004
1	AutoantibodiesIBA 01/2022
1	Chimeric Antigen ReceptorsIBA 01/2022
1	AntibodiesIBA 01/2021
1	Proteins (Proteins, Gene)FDA Link 01/2021
1	Anti-Citrullinated Protein AntibodiesIBA 10/2016
1	HLA Antigens (Human Leukocyte Antigens)IBA 10/2016
1	Fingolimod Hydrochloride (FTY720)FDA Link 01/2016
1	Immunodominant EpitopesIBA 09/2006
1	CollagenIBA 04/2005
1	HLA-DR4 Antigen (HLA DR4 Antigen)IBA 04/2004
1	TolerogenIBA 01/2002

Therapy/Procedure

1	Immunotherapy 01/2022